Abemaciclib Impurity 30 DiHCl CAS 2124229-65-6 (free base)
| CAS No. | 2124229-65-6 (free base) |
| Molecular Formula | C18H31N5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Abemaciclib Impurity 30 DiHCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Abemaciclib Impurity 30 DiHCl (CAS 2124229-65-6 (free base), C18H31N5HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Abemaciclib Impurity 30 DiHCl (C18H31N5HCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H31N5 2*HCl |
| Molecular Weight | 353.94 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Abemaciclib Standards
- Abemaciclib Impurity N5 (CAS 1038408-36-4)
- Abemaciclib Impurity 21 (CAS 1178566-47-6 (free base))
- Abemaciclib (CAS 1231929-97-7)
- Abemaciclib Impurity N2 (CAS 1231930-29-2)
- Abemaciclib Impurity N4 (CAS 1231930-33-8)
- Abemaciclib Impurity N7 (CAS 1231930-37-2)
- Abemaciclib Impurity N3 (CAS 1231930-42-9)
- Abemaciclib Impurity 70 (CAS 1231930-47-4)
Recommended Standards
- Rtitrexed Impurity 28 (CAS CATO-C4X-138628)
- Nafamostat Impurity 67 (CAS 2491698-53-2)
- Crisaborole Impurity 55 (CAS CATO-C4X-202155)
- N-(1,3-Dimethylimidazolidin-2-ylidene)isoquinolin-5-amine (CAS 828258-30-6)
- N-(2-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propionamide (CAS 1912446-94-6)
- 7-Chlorofuro[3,4-c]pyridine (CAS 1211511-96-4)
- 1-(6-Methyl-3,4-dihydroquinolin-1(2h)-yl)ethan-1-one (CAS 105340-58-7)
- Ethylgermanium trichloride, min. 97% (CAS 993-42-0)
- 3-(2-Chloro-4-methoxyphenyl)acrylic acid (CAS 1369477-55-3)
- Tirzepatide Impurity 59 (CAS CATO-C4X-324059)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com